Organic Chemistry

Impact of new Halogenated Tryptophan Derivatives on Psychedelic Research

Groundbreaking research has demonstrated the potential for enzymes to selectively halogenate tryptophan at the 5-, 6-, or 7- positions, with particular emphasis on the 7- position, opening up opportunities to expand bio-based production to different hosts and halogenation positions within tryptophan, making it relevant for a cheaper large-scale industrial production of tryptophan pharmaceutical derivatives.

In the realm of psychedelics, this method could lead to the development of various tryptamine-based psych*delics and new halogenated beta-carbolines that can be used as alternatives to MAOIs in pharmahuasca blends. The possibilities are vast and exciting.

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Molecular Art with Dr. Mike McCormick (xtal_xlear)

Art usually focuses on physical objects, viewpoints, or even the imaginary, but how about what is invisible to the human eye and can only be seen at a molecular level?

We spoke to the crystallographer Dr.Mike McCormick (@xtal_xlear) to understand more about his artwork and how portraying molecules in the form of art may cultivate interest in the fields of chemistry to the masses.

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Importance of Biotechnology in psychedelics with Huan Shuma

Biotechnology has been a recurrent theme in the research of psychedelics. However, we don’t hear much about its importance. To find out the impacts of Biotechnology not only in psychedelics but in the world, we spoke or Arthur Dempsey (chavin_herbalists), covering themes such as propagation of species, genetic banks of species, improvement of genetics, how he became the first seed producer of Argyreia in Brazil, the creation of his Rare plant and Trichocereus Seed Bank, how can we save the Amazon Rainforest and ancient teachings by the Brazilian indigenous communities.

A Biotecnologia tem sido um tema recorrente na pesquisa dos psicodélicos. No entanto, não ouvimos muito sobre a sua importância. Para descobrir os impactos da Biotecnologia não apenas nos psicodélicos, mas no mundo, conversamos com Arthur Dempsey (chavin_herbalists), abordando temas como a propagação de espécies, bancos genéticos de espécies, melhoria genética, como ele se tornou o primeiro produtor de sementes de Argyreia no Brasil, a criação do seu Banco de Sementes de Plantas Raras e Trichocereus, como podemos salvar a Floresta Amazônica e os ensinamentos ancestrais das comunidades indígenas brasileiras.

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Origins of Ethnopharmacology

Aspirin, Digoxin, and Morphine aren’t the first thing that comes to our minds once we hear the word Plant Medicine. Regardless of their seemingly distant origin, all those compounds once had a plant origin. To this, we name ethnopharmacology. Using the word of Juerg Gertsch: “Ethnopharmacology tries to understand the pharmacological basis of culturally important plants.”

Today, ethnopharmacology has an equally important role, as we are using plants that have been used for centuries by natives. Plants such as Peyote, Ayahuasca, Iboga, Kava Kava, and Psilocybe aid us with the current mental illness epidemic. Thus, Indigenous communities are once again furnishing us and aiding us with their ancient knowledge, this being said it would only be unfair not to feature such communities in Psychedelic and Ethnobotanical conferences, giving them their due credit, and teaching us about how much these plants mean to their culture, and most importantly how we should respect and protect indigenous rights.

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The new religion of Psilomethoxin

The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it.

However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it’s yet incognito whether the compound could have any neurotoxicity.

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