Chemistry

Entourage effect of Peyote

The entourage effect is a phenomenon that has been gaining traction in psychedelic research. What at first was thought to be a phenomenon observed solemnly in the cannabis community and the entourage effect between THC and other phytocannabinoids turns out to be much more extensive than what we thought to be and to influence several species such as the Psilocybe genus. One specific study highlighted the significance of this phenomenon by demonstrating the superior therapeutic accuracy of psilocybin extracts compared to synthetic psilocybin.

However, there is a species that hasn’t been spoken of enough when mentioning the entourage effect. Lophophora Williamsii (Peyote).

Join us and understand the entourage effect in Peyote!

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Impact of new Halogenated Tryptophan Derivatives on Psychedelic Research

Groundbreaking research has demonstrated the potential for enzymes to selectively halogenate tryptophan at the 5-, 6-, or 7- positions, with particular emphasis on the 7- position, opening up opportunities to expand bio-based production to different hosts and halogenation positions within tryptophan, making it relevant for a cheaper large-scale industrial production of tryptophan pharmaceutical derivatives.

In the realm of psychedelics, this method could lead to the development of various tryptamine-based psych*delics and new halogenated beta-carbolines that can be used as alternatives to MAOIs in pharmahuasca blends. The possibilities are vast and exciting.

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Molecular Art with Dr. Mike McCormick (xtal_xlear)

Art usually focuses on physical objects, viewpoints, or even the imaginary, but how about what is invisible to the human eye and can only be seen at a molecular level?

We spoke to the crystallographer Dr.Mike McCormick (@xtal_xlear) to understand more about his artwork and how portraying molecules in the form of art may cultivate interest in the fields of chemistry to the masses.

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Importance of Biotechnology in psychedelics with Huan Shuma

Biotechnology has been a recurrent theme in the research of psychedelics. However, we don’t hear much about its importance. To find out the impacts of Biotechnology not only in psychedelics but in the world, we spoke or Arthur Dempsey (chavin_herbalists), covering themes such as propagation of species, genetic banks of species, improvement of genetics, how he became the first seed producer of Argyreia in Brazil, the creation of his Rare plant and Trichocereus Seed Bank, how can we save the Amazon Rainforest and ancient teachings by the Brazilian indigenous communities.

A Biotecnologia tem sido um tema recorrente na pesquisa dos psicodélicos. No entanto, não ouvimos muito sobre a sua importância. Para descobrir os impactos da Biotecnologia não apenas nos psicodélicos, mas no mundo, conversamos com Arthur Dempsey (chavin_herbalists), abordando temas como a propagação de espécies, bancos genéticos de espécies, melhoria genética, como ele se tornou o primeiro produtor de sementes de Argyreia no Brasil, a criação do seu Banco de Sementes de Plantas Raras e Trichocereus, como podemos salvar a Floresta Amazônica e os ensinamentos ancestrais das comunidades indígenas brasileiras.

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Harm reduction 101: The harm reduction guide

This harm-reduction series will be sharing tips on how to have safe trips. Covering subjects such as psychedelic therapy, and psychedelic retreats, the importance of testing your compounds, set and setting, and the importance of having a plan and using a trip sitter.

In this chapter, we will be focusing on the importance of testing your substances and when to use each reagent, what is set and setting and their importance, the importance of tripsitters (buddy-system), and how to create a safety plan when using psychedelics.

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Harm reduction 101: Psychedelic therapy and psychedelic retreats

This harm-reduction series will be sharing tips on how to have safe trips. Covering subjects such as psychedelic therapy, and psychedelic retreats, the importance of testing your compounds, set and setting, and the importance of having a plan and using a trip sitter.

In this chapter, we will be covering the misconception of psychedelics alone being able to heal mental illnesses, and the processes behind psychedelic therapy, including what is integration, types of integration, and how to be safe in international retreats.

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ATOMIC PROBLEMS

Extremium and Niton aren’t part of our scientific vocabulary today, however, they once were.
In this article, we delve into the creation of new elements, who is the identity responsible for their nomenclature, and Victor Ninov the man who tried to fool the world by faking an element.

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Stories of a modern opioid eater

From Daquince’s use of opium to the modern era, many stories of opioid users have been lost. For that reason, we cover the stories of two opioid- users Benzzzy and Calvin, from what led them to their addiction, their difficulties during this period, their advice for people who might be going through addiction, and their current status.

In addition, we discuss the pharmacology student Anthony Furrule (@science_and_anonymous) about opioid prescription, opioid alternatives, the use of Ibogaine or its analogs for the treatment of addiction, and Narcan-resistant Fentanyl.

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Origins of Ethnopharmacology

Aspirin, Digoxin, and Morphine aren’t the first thing that comes to our minds once we hear the word Plant Medicine. Regardless of their seemingly distant origin, all those compounds once had a plant origin. To this, we name ethnopharmacology. Using the word of Juerg Gertsch: “Ethnopharmacology tries to understand the pharmacological basis of culturally important plants.”

Today, ethnopharmacology has an equally important role, as we are using plants that have been used for centuries by natives. Plants such as Peyote, Ayahuasca, Iboga, Kava Kava, and Psilocybe aid us with the current mental illness epidemic. Thus, Indigenous communities are once again furnishing us and aiding us with their ancient knowledge, this being said it would only be unfair not to feature such communities in Psychedelic and Ethnobotanical conferences, giving them their due credit, and teaching us about how much these plants mean to their culture, and most importantly how we should respect and protect indigenous rights.

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The new religion of Psilomethoxin

The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it.

However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it’s yet incognito whether the compound could have any neurotoxicity.

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