The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it. However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it's yet incognito whether the compound could have any neurotoxicity.

In a conversation with the pharmacy student Iara Martinez, we delve into her interest and experiences in the world of psychedelics, how these compounds aided her in mental illness, as well as the steps to becoming a psychedelic therapist.

Phallic shapes are all over the psychedelic world. From as the Penis-Envy strain to the Penis cactus, in this article we learn more about the origins of this species and how this rare cactus has seduced the community over the years.

Despite being fairly misunderstood, John C.Lilly has contributed to science, metaphysics, neuroscience, and the realms of consciousness. This year as a mark the 21st year after his death we deep dive into Lilly's work on dolphins, ketamine, and the province of the mind.

In a conversation with the research chemist and student Anthony Furrule (science_and_anonymous), we discuss the importance of education during the Psychedelic Renaissance, harm reduction, and the difficulties of being a social media scientific educator.

In the loving memory of the Shulgins the article Living and Loving through chemistry will teach you about Sasha's course to find 234 psychedelics alongside his wife Ann and learn how you can have a voice against DEA attempts to make substances illegal.

Nitrous Oxide or Dephlogisticated nitrous air named by its discoverer Joseph Priestley has always been a promising anesthetic and a possible treatment for depression until today, unfortunately, the gas has become a worry in the UK due to its misuse.

Radioactivity has been indulged as something inherently bad majorly after the explosions in the Chornobyl plants. Despite its dangers radioactivity has brought an evolution in the scientific realm as well as allowed the creation of DOI, DOB and 2C-I.

Since the introduction of the Psilocybe genus to the western community, various genetic engineering experiences were made birthing various strains, among them the WillSolvem Peyote Strain. Recent revolutionary research conducted by the Usona Institute unveiled for the first time the true crystal structure of psilocybin opening doors for new psilocybin analogs, such as CYB003, believed to hold the potential to treat major depressive disorder (MDD) and alcohol disorder. This analog is designed to have less variability in the plasma levels, a faster onset of action, shorter duration, and potentially be more tolerable versus oral psilocybin. Along with the mycological and chemical discoveries, how the substance acts in the brain and its potential use for the treatment of clinical depression is also being explored together with the hypothesis of psilocybe altering the gut microbiome, thus creating a potential avenue for new pharmaceutical tools targeting the gut-brain axis.

The scarcity of the Incilius Alvarius in the wild brought preoccupation regarding the future of the toads, consequently the future of 5-MeO-DMT. In a conversation with the founder of Egret Bio, Phillipe Henry, and the founder of Lighthouse Genomics Timothy Harvey we were able to understand more about their project Alvarius Research. A project focused on conserving, decoding and editing the genome of the species as well as granting us the biosynthetic reproduction of toad cells.

Natural from the Sierra Mazateca, Salvia Divinorum is well known amongst Shamans, however, not much is known about the variations within the species remaining a chemical mystery.

Since the pre-Hispanic times, tribes such as the Zapotecs, Chinantecs, Mazatecs, and Mixtecs used Morning glory seeds (Ololiuqui), despite the hallucinatory and vasoconstriction effects, E.T Brady Jr from the Ross General Hospital believes the effects can be reversed using chlorpromazine in addition to psychiatric consultation to aid mental health building a bridge between ancient shamanism and modern psychopharmacology.

Despite its popularity as a party drug cocaine has chewed and consumed an ash mixture going by the name of Mambe by various indigenous tribes in the Amazon rainforest and clinically in western societies for centuries, these practices remained until today reasoning why the compound remains a Schedule II drug.

As the Pandemic progresses, the use of Opioids raised massively, with the increase of built-in stress, augmentation of cases of depression, anxiety, and ADHD, people often search for alternatives for their prescribed medication as they are afraid to get hooked into it. In 2020 Kratom took a major step towards its legalization, further information will be discussed by the Royal Thai Gazette, recent studies predict the binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids and users claim that Kratom could be an alternative for their prescription for their mental health.

A duality of realities from two different types of tobacco consumerism, the contrast between the use of the plant in Native American tribes where the plant is considered sacred and the use in Western Societies where the plant is known to be an addiction.