Pharmacology

Impact of new Halogenated Tryptophan Derivatives on Psychedelic Research

Groundbreaking research has demonstrated the potential for enzymes to selectively halogenate tryptophan at the 5-, 6-, or 7- positions, with particular emphasis on the 7- position, opening up opportunities to expand bio-based production to different hosts and halogenation positions within tryptophan, making it relevant for a cheaper large-scale industrial production of tryptophan pharmaceutical derivatives.

In the realm of psychedelics, this method could lead to the development of various tryptamine-based psych*delics and new halogenated beta-carbolines that can be used as alternatives to MAOIs in pharmahuasca blends. The possibilities are vast and exciting.

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Women Authors in Psychedelics: Celebrating Women’s History Month

Celebrate Women’s History Month with us!
Join us in honoring the incredible contributions of female authors in the realm of psychedelics.

We’re excited to showcase a diverse array of voices, each bringing unique perspectives, captivating stories, and groundbreaking research.

Dive into the fascinating world of psychedelics with our curated selection of newly released books. From personal journeys to scientific exploration, these books offer profound insights and thought-provoking narratives that enrich your understanding of psychedelics and their potential.

Support female writers and their invaluable contributions to the psychedelic discourse by adding these remarkable books to your collection.

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Cannabis and exercise

Cannabis has been a part of our society for ages. With the legalization of the plant in various states, the words Terpenes, Cannabinoids, and Cannabis have been louder than ever, raising questions about various topics, one of them exercise.

Athletes and workout enthusiasts have recently entered the world of Cannabis to benefit from the muscle relaxation and pain relief effects of the plant. Unfortunately, to those who compete at a professional level, smoking is often not possible. So we might question ourselves, how can I consume Cannabis without smoking it?

To figure out various forms of consumption of the plant and how Cannabis can help athletes or during exercise, tips on how to implement working out into your routine, and what CBD is, we spoke to the molecular biologist and weight-lifter Suat Neven.

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Molecular Art with Dr. Mike McCormick (xtal_xlear)

Art usually focuses on physical objects, viewpoints, or even the imaginary, but how about what is invisible to the human eye and can only be seen at a molecular level?

We spoke to the crystallographer Dr.Mike McCormick (@xtal_xlear) to understand more about his artwork and how portraying molecules in the form of art may cultivate interest in the fields of chemistry to the masses.

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Atropine witches, a story of medieval potions

With the approach of the night of Halloween, we uncover what it meant to be a witch during the medieval era, why they were hunted down and burned, and the influence of Christianism in non-Christian cultures such as Mazatecs and Native Americans, Modern-day witches, and the fact you may be practicing witch rituals without knowing, botanical name codes for witches, what is inside a witch potion or brew, the use of Atropine, and Scopolamine in Medieval era and their pharmacological use today and their pharmacodynamics.

We hope you enjoy your Halloween!

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LSD lemurs and millipedes with Daniela Bolanos Garcia

The case of Professor John Buettner-Janusch is the biggest scandal around the University of NY, from synthesizing one kilo of Quaaludes and LSD to supposedly give to lemurs (where he gained his nickname Professor Quaalude) to attempting to poison the federal judge responsible for his case. Janusch claimed he had given LSD and Quaaludes to his primates to study their emotional behavior while under the influence of these compounds. However, in the wild, we have also heard that lemurs get high using hallucinogenic millipedes. To get down to these claims, we had a conversation the Tropical Biology student Daniela Bolanos Garcia to understand why they do it, whether they are consciously getting high, and what makes them high!

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Harm reduction 101: The harm reduction guide

This harm-reduction series will be sharing tips on how to have safe trips. Covering subjects such as psychedelic therapy, and psychedelic retreats, the importance of testing your compounds, set and setting, and the importance of having a plan and using a trip sitter.

In this chapter, we will be focusing on the importance of testing your substances and when to use each reagent, what is set and setting and their importance, the importance of tripsitters (buddy-system), and how to create a safety plan when using psychedelics.

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Harm reduction 101: Psychedelic therapy and psychedelic retreats

This harm-reduction series will be sharing tips on how to have safe trips. Covering subjects such as psychedelic therapy, and psychedelic retreats, the importance of testing your compounds, set and setting, and the importance of having a plan and using a trip sitter.

In this chapter, we will be covering the misconception of psychedelics alone being able to heal mental illnesses, and the processes behind psychedelic therapy, including what is integration, types of integration, and how to be safe in international retreats.

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Stories of a modern opioid eater

From Daquince’s use of opium to the modern era, many stories of opioid users have been lost. For that reason, we cover the stories of two opioid- users Benzzzy and Calvin, from what led them to their addiction, their difficulties during this period, their advice for people who might be going through addiction, and their current status.

In addition, we discuss the pharmacology student Anthony Furrule (@science_and_anonymous) about opioid prescription, opioid alternatives, the use of Ibogaine or its analogs for the treatment of addiction, and Narcan-resistant Fentanyl.

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Origins of Ethnopharmacology

Aspirin, Digoxin, and Morphine aren’t the first thing that comes to our minds once we hear the word Plant Medicine. Regardless of their seemingly distant origin, all those compounds once had a plant origin. To this, we name ethnopharmacology. Using the word of Juerg Gertsch: “Ethnopharmacology tries to understand the pharmacological basis of culturally important plants.”

Today, ethnopharmacology has an equally important role, as we are using plants that have been used for centuries by natives. Plants such as Peyote, Ayahuasca, Iboga, Kava Kava, and Psilocybe aid us with the current mental illness epidemic. Thus, Indigenous communities are once again furnishing us and aiding us with their ancient knowledge, this being said it would only be unfair not to feature such communities in Psychedelic and Ethnobotanical conferences, giving them their due credit, and teaching us about how much these plants mean to their culture, and most importantly how we should respect and protect indigenous rights.

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