First atlas of the whole human brain at the single-cell level: What does it mean for Psychedelic Research?

On October 13, 2023, a team of researchers created the most extensive atlas of the human brain thus far, revealing more than 3,000 cell types, including many new to the scientific world. In the atlas, we can observe snapshots of the most complex organ known to man, the brain.

But what does this atlas mean to psychedelic research?

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DiPT, the symphonia of emotion

Have you ever wondered how music influences our mood and our brain? Who invented music? Would modulating our perception of sound change the way we hear our favorite musicians? And most importantly, how can someone change their perception of sound?

Millions of people listen to music daily, utilizing terminology from the classical media, we are in a “music epidemic”. Despite not being fairly noticed, music does modulate our feelings and has an impact on our neural networks, reasoning why you will listen to sad songs when you are feeling melancholic, and happy songs when you are in a state of bliss. All those feelings are caused by a change in our brain chemistry.

Now let us hypothesize that one would be able to change how we perceive sound, would that change how we feel about a certain song? Absolutely! Raising the question how would someone do that? To answer that, we dive into Alexander Shulgin’s magnum opus TiHKAL, to a compound under the name DiPT, a compound known for its auditory hallucinations and distortion of sound.

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Psilocybin In the brain

Since the introduction of the Psilocybe genus to the western community, various genetic engineering experiences were made birthing various strains, among them the WillSolvem Peyote Strain.

Recent revolutionary research conducted by the Usona Institute unveiled for the first time the true crystal structure of psilocybin opening doors for new psilocybin analogs, such as CYB003, believed to hold the potential to treat major depressive disorder (MDD) and alcohol disorder. This analog is designed to have less variability in the plasma levels, a faster onset of action, shorter duration, and potentially be more tolerable versus oral psilocybin.

Along with the mycological and chemical discoveries, how the substance acts in the brain and its potential use for the treatment of clinical depression is also being explored together with the hypothesis of psilocybe altering the gut microbiome, thus creating a potential avenue for new pharmaceutical tools targeting the gut-brain axis.

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