PsychedelicsASL

I am a writer focused on the study of psychedelics and pharmacology. Writer of Lophophora as a second language.

Amanita in a nutshell: The birth of Gaboxadol and pharmacological value of Amanita

After covering the cultural impact of Amanita Muscaria, we dive into the influence of the mushroom on the chemist Povl Krogsgaard-Larsen and the birth of Gaboxadol.

How the mushroom became popularized as a recreational drug, how to find your dosage, the effects of Amanita Muscaria, and the potential of the mushroom as a therapeutic tool, as an anti-inflammatory and anti-cancer agent.

We understand how Amanita Muscaria can be used to help with anxiety, autism, and panic disorder by looking up to the story of the YouTuber Amanita Dreamer.

And how, despite the constant arguing about whether the mushroom is neurotoxic or not, Amanita Muscaria made its way into being a delicacy, being served as ice cream in France (including our recreation of the 1909 recipe) and pickled in Japan under the name BENI-TENGU-DAKE.

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Amanita Muscaria In a nutshell: The cultural impact of the fly agaric

Fungi are all around the world, paving Earth through mycelial networks. Some fungi remain obscure due to their rare nature. Meanwhile, some became nurtured by our society and vividly present in our culture and traditions as well as a representative of the mushroom kingdom. We are talking about the unique and fascinating Amanita Muscaria.

The historical use of Amanita still roams slightly on the mysterious side, as R. Gordon Wasson theorizes that the Soma drink mentioned in the Vedic Sanskrit hymn Rig Veda might be Amanita Muscaria. If this theory is correct, this would mean that the mushroom has been used for around 4000 years.

Unfortunately, we still lack evidence, leaving us with the only historically accurate use of this mushroom amongst the Fino-Ungarians in Siberia.

Amanita Muscaria would soon expand and become engrained in our culture until today, being present in children’s books, playgrounds, cartoons, riddles, and video games.

Amanita’s cultural impact goes even beyond when Jonathan Ott linked this mushroom and Christmas, relating the red and white pattern of Amanita with the clothing pattern of Saint Nicholas (Santa Claus) and the flying reindeer with ingesting the reindeer urine after they had eaten the mushroom by tribes in Siberia. Flying reindeer could also represent the reindeer that ate the mushroom.

James Arthur marked these links even further in his book Mushrooms and Mankind, linking the Christmas tree and gifts wrapped in red and white below the tree to the symbiosis between the roots of coniferous trees and the mycelial networks of the Amanita Muscaria shroom.

Regardless of its continuous presence in Children’s tales, don’t be mistaken. This mushroom is no child’s play.

Throughout time, the discussion regarding the toxicity of Amanita Muscaria has been continuous. Some believe that the fungus is poisonous due to containing the neurotoxin ibotenic acid. Meanwhile, others say that the mushroom is safe after being prepared correctly, and some go further and say that eating the mushroom without any preparation is safe.

Contrary to popular belief, Amanita Muscaria has no resemblance to other magic mushrooms and works in a completely different way.

Unlike the psilocybe genus, the fly agaric doesn’t have psilocybin or any serotonergic compound. Instead, the mushroom contains muscarine and muscimol.

Muscimol, also known as agarin or pantherine, works very differently from classic psychedelics. The compound is a potent GABA-A agonist, acting as an oneirogen (sedative/hypnotic), subjectively similar to the hypnotic drug Ambien (Zolpidem).

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Ergot: From Iberian Ergot Markets to LSD renaissance

Since the ’60s, the word LSD has been amongst us quite frequently, especially nowadays, with traditional therapies being replaced by psychedelic retreats and micro-dosing. But where does exactly LSD come from? Is it purely synthetic, or does it come from nature?

Believe it or not, it comes from a fungus widely known since 500 to 1500 CE, Ergot. This fungus works similarly to puffballs and carries ergot alkaloids. Funnily enough, when Albert Hofmann synthesized LSD, he wasn’t trying to synthesize a psychedelic but trying to find more ergot alkaloids that historically have been used to speed up labor and control postpartum hemorrhage and as a treatment for patients with moderate to severe migraine.

Unfortunately, things were much darker during the Medieval era. Ergot would infect rye and various kinds of cereal, and after consumption of the infected cereals, people would become ill with ergotism. Ergotism plagues were known as Saint Anthony’s Fire for their mild effects. Often, people would experience convulsions, seizures, spasms, diarrhea, paresthesia, severe itching and burning sensation (hence, its nickname St. Anthony’s fire), headaches, nausea and vomiting, and mental effects such as hallucinations, mania, and psychosis until their death.

You might think, well, that is all over now. We can’t have ergot contamination nowadays, right?

The answer to this might surprise you negatively. We still have the chance of infection of crops. The infection can expand to the poisoning of farm stocks, causing gangrene in the extremities of animals that feed in contaminated fields. Fortunately, with the control of food sold in markets, it would be nearly impossible for an outbreak similar to those during the medieval era.

But where did Ergot come from? They were using it clinically to speed up labor and control postpartum hemorrhage during a period.

Most of the Ergot would come from Portugal and the Northwest Spain. During that period, the fungus was valuable and impacted the capita of these countries. Peasants would collect the fungus by hand, and the owners of the land would take the items to an Ergot dealer that would ship the product worldwide.

Leaving us with one last question.

With the psychedelic renaissance and the movement towards legalization of psychedelics, will we get to see the cultivation and selling of Ergot available after centuries of prohibition?

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Cannabis and exercise

Cannabis has been a part of our society for ages. With the legalization of the plant in various states, the words Terpenes, Cannabinoids, and Cannabis have been louder than ever, raising questions about various topics, one of them exercise.

Athletes and workout enthusiasts have recently entered the world of Cannabis to benefit from the muscle relaxation and pain relief effects of the plant. Unfortunately, to those who compete at a professional level, smoking is often not possible. So we might question ourselves, how can I consume Cannabis without smoking it?

To figure out various forms of consumption of the plant and how Cannabis can help athletes or during exercise, tips on how to implement working out into your routine, and what CBD is, we spoke to the molecular biologist and weight-lifter Suat Neven.

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Molecular Art with Dr. Mike McCormick (xtal_xlear)

Art usually focuses on physical objects, viewpoints, or even the imaginary, but how about what is invisible to the human eye and can only be seen at a molecular level?

We spoke to the crystallographer Dr.Mike McCormick (@xtal_xlear) to understand more about his artwork and how portraying molecules in the form of art may cultivate interest in the fields of chemistry to the masses.

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Atropine witches, a story of medieval potions

With the approach of the night of Halloween, we uncover what it meant to be a witch during the medieval era, why they were hunted down and burned, and the influence of Christianism in non-Christian cultures such as Mazatecs and Native Americans, Modern-day witches, and the fact you may be practicing witch rituals without knowing, botanical name codes for witches, what is inside a witch potion or brew, the use of Atropine, and Scopolamine in Medieval era and their pharmacological use today and their pharmacodynamics.

We hope you enjoy your Halloween!

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First atlas of the whole human brain at the single-cell level: What does it mean for Psychedelic Research?

On October 13, 2023, a team of researchers created the most extensive atlas of the human brain thus far, revealing more than 3,000 cell types, including many new to the scientific world. In the atlas, we can observe snapshots of the most complex organ known to man, the brain.

But what does this atlas mean to psychedelic research?

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Remembering Roland Griffiths

The heartbreaking news of Dr.Roland Griffiths’s passing was given to the world yesterday, October 17th. Griffiths was diagnosed with Stage 4 metastatic colon cancer at 76.

Despite his diagnosis to be terminal, he remained optimistic about existence. In an interview with the New York Times, he reminded us that we all are mortal quoting. “We all know that we’re terminal.”

Dr.Griffiths was an illustrious psychopharmacology professor at Johns Hopkins and spent decades studying the mechanism of mood-altering drugs. During his research, he published over 400 scientific papers on opiates and cocaine, sedatives and alcohol, and nicotine and caffeine.

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DMT vs 5-MeO-DMT

With the popularization of terms such as “Toad Medicine” or “5-MeO”, people began to wonder about the differences between DMT and 5-MeO-DMT.

Generally, you might come across misinformation regarding the differences between the two. Because of its name, people believe that 5-MeO-DMT is just like DMT, and it all feels the same. “It’s all DMT at the end of the day.”

For this reason, we decided to cover the differences between DMT and 5-MeO-DMT.

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Importance of Biotechnology in psychedelics with Huan Shuma

Biotechnology has been a recurrent theme in the research of psychedelics. However, we don’t hear much about its importance. To find out the impacts of Biotechnology not only in psychedelics but in the world, we spoke or Arthur Dempsey (chavin_herbalists), covering themes such as propagation of species, genetic banks of species, improvement of genetics, how he became the first seed producer of Argyreia in Brazil, the creation of his Rare plant and Trichocereus Seed Bank, how can we save the Amazon Rainforest and ancient teachings by the Brazilian indigenous communities.

A Biotecnologia tem sido um tema recorrente na pesquisa dos psicodélicos. No entanto, não ouvimos muito sobre a sua importância. Para descobrir os impactos da Biotecnologia não apenas nos psicodélicos, mas no mundo, conversamos com Arthur Dempsey (chavin_herbalists), abordando temas como a propagação de espécies, bancos genéticos de espécies, melhoria genética, como ele se tornou o primeiro produtor de sementes de Argyreia no Brasil, a criação do seu Banco de Sementes de Plantas Raras e Trichocereus, como podemos salvar a Floresta Amazônica e os ensinamentos ancestrais das comunidades indígenas brasileiras.

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