Chemistry

Stories of a modern opioid eater

From Daquince’s use of opium to the modern era, many stories of opioid users have been lost. For that reason, we cover the stories of two opioid- users Benzzzy and Calvin, from what led them to their addiction, their difficulties during this period, their advice for people who might be going through addiction, and their current status.

In addition, we discuss the pharmacology student Anthony Furrule (@science_and_anonymous) about opioid prescription, opioid alternatives, the use of Ibogaine or its analogs for the treatment of addiction, and Narcan-resistant Fentanyl.

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Origins of Ethnopharmacology

Aspirin, Digoxin, and Morphine aren’t the first thing that comes to our minds once we hear the word Plant Medicine. Regardless of their seemingly distant origin, all those compounds once had a plant origin. To this, we name ethnopharmacology. Using the word of Juerg Gertsch: “Ethnopharmacology tries to understand the pharmacological basis of culturally important plants.”

Today, ethnopharmacology has an equally important role, as we are using plants that have been used for centuries by natives. Plants such as Peyote, Ayahuasca, Iboga, Kava Kava, and Psilocybe aid us with the current mental illness epidemic. Thus, Indigenous communities are once again furnishing us and aiding us with their ancient knowledge, this being said it would only be unfair not to feature such communities in Psychedelic and Ethnobotanical conferences, giving them their due credit, and teaching us about how much these plants mean to their culture, and most importantly how we should respect and protect indigenous rights.

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The new religion of Psilomethoxin

The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it.

However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it’s yet incognito whether the compound could have any neurotoxicity.

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Understanding the future of 5-MeO-DMT with Phillipe Henry and Timothy Harvey

The scarcity of the Incilius Alvarius in the wild brought preoccupation regarding the future of the toads, consequently the future of 5-MeO-DMT.
In a conversation with the founder of Egret Bio, Phillipe Henry, and the founder of Lighthouse Genomics Timothy Harvey we were able to understand more about their project Alvarius Research. A project focused on conserving, decoding and editing the genome of the species as well as granting us the biosynthetic reproduction of toad cells.

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Morning Glory, the ancient LSA experience

Since the pre-Hispanic times, tribes such as the Zapotecs, Chinantecs, Mazatecs, and Mixtecs used Morning glory seeds (Ololiuqui), despite the hallucinatory and vasoconstriction effects, E.T Brady Jr from the Ross General Hospital believes the effects can be reversed using chlorpromazine in addition to psychiatric consultation to aid mental health building a bridge between ancient shamanism and modern psychopharmacology.

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