Psychedelic Research

JRT a new Lysergamide in the Horizon?

By altering the position of two atoms in the molecular structure of LSD, a team at UC Davis created the new compound named JRT and published the discovery on April 14th, five days before Bicycle Day.

The subtle change preserved the ability of the drug to stimulate brain cell growth and repair damaged neural connections, key features in treating cognitive decline while minimizing the psychedelic effects.

When given to mice, JRT has powerful neuroplastic effects and improved measures of the negative and cognitive symptoms of schizophrenia without showing behaviors and gene expression associated with psychosis.

“The development of JRT emphasizes that we can use psychedelics like LSD as starting points to make better medicines. We may be able to create medications that can be used in patient populations where psychedelic use is precluded.” – David Olson, director of the Institute for Psychedelics and Neurotherapeutics and professor of chemistry, biochemistry, and molecular medicine at UC Davis.

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Zebrafish might be the future of studying neuroactive compounds

PsychedelicsASL

Fully understanding the mechanisms of action of neuroactive compounds is difficult due to their complexity and polypharmacology. Making single-target drug discovery nearly impossible.

Phenotypic screening was one of the solutions brought by science. However, this method faced historical limitations until recently.

A group of researchers from the University of California found a way to rapidly profile thousands of compounds using larval zebrafish, which share genetics and CNS anatomy with humans, making complex behavioral readouts possible.

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Are psychedelics suitable for me?

PsychedelicsASL

Since the commercialization of legal psychedelic products, plenty of comments about psychedelics being miracle drugs that can cure mental illnesses in one use began to come to the surface, but are psychedelics really miracle drugs, and most importantly, how do I know if psychedelics are suitable for me? Figure out the answers to these questions here!

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One step closer to saving a species!

PsychedelicsASL

In the last five years, two words have spread like wildfire, “Toad Medicine” (5-MeO-DMT) is in the mouths of celebrities, herpetologists, psychonauts, and curious people. This curiosity narrowed Incilius Alvarius to endangerment due to poaching and increased movement on the Sonoran roads. Fortunately, researchers at Mount Sinai Hospital and Columbia University greeted us with another synthetic alternative to stop harming the toads 4-F,5-MeO-PyrT.

Could this be a queue to stop seeing this toad as a “medicine” and see it as a living species once again and stop abusing it for personal benefit?

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What is shadow work?

PsychedelicsASL

In the intricate landscape of human psychology, the concept of the shadow self, as elucidated by Carl Jung, represents the latent and often repressed aspects of our personality. Emerging research suggests that psychedelics, particularly empathogens-entactogens such as MDMA and 2C-B, may serve as catalysts for unveiling these hidden dimensions.

Through controlled clinical settings and guided therapy, individuals undergoing psychedelic experiences have reported profound insights into their shadow selves, leading to enhanced self-awareness and psychological integration.

Join us in examining personal anecdotes, confronting the intersection of untreated shadow manifestations and the transformative potential of psychedelic-assisted therapy.

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Prehistoric Psilocybin

PsychedelicsASL

Ethnobotanicals are the most antique forms of psychedelic consumption, but for how long have they been around? We have proof of human and animal ingestion around 3,000 years ago, but could species before have also presented the existence of such species?

A newly published study from the University of Utah and the Natural History Museum of Utah suggests that the Psilocybe genus could be around about 65 million years ago!

Join us to uncover a hypothesis of why the genus started developing psilocybin and the first appearance of the fungi during prehistory.

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Women Authors in Psychedelics: Celebrating Women’s History Month

PsychedelicsASL

Celebrate Women’s History Month with us!
Join us in honoring the incredible contributions of female authors in the realm of psychedelics.

We’re excited to showcase a diverse array of voices, each bringing unique perspectives, captivating stories, and groundbreaking research.

Dive into the fascinating world of psychedelics with our curated selection of newly released books. From personal journeys to scientific exploration, these books offer profound insights and thought-provoking narratives that enrich your understanding of psychedelics and their potential.

Support female writers and their invaluable contributions to the psychedelic discourse by adding these remarkable books to your collection.

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Remembering Roland Griffiths

PsychedelicsASL

The heartbreaking news of Dr.Roland Griffiths’s passing was given to the world yesterday, October 17th. Griffiths was diagnosed with Stage 4 metastatic colon cancer at 76.

Despite his diagnosis to be terminal, he remained optimistic about existence. In an interview with the New York Times, he reminded us that we all are mortal quoting. “We all know that we’re terminal.”

Dr.Griffiths was an illustrious psychopharmacology professor at Johns Hopkins and spent decades studying the mechanism of mood-altering drugs. During his research, he published over 400 scientific papers on opiates and cocaine, sedatives and alcohol, and nicotine and caffeine.

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LET’S KEEP IN TOUCH!