Pharmacology

Psychedelic Individualism, a shift on purpose

Recently, there was a shift in Entheogens.

A shift in our purpose.

Entheogens once used to unite the community and are now met with individualism. This shift is nothing but a representation of our society.

We are beginning to absolve the sense of community and become focused on ourselves. Losing communion, compassion, love, and respect for others.

This might be an inevitable step for the evolutionary step, the German band Kraftwerk named Mensch-Maschine (Man-Machine).

Yet, Entheogens can still be the turning point for us to become a community once again.

Find out more!

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Why do we take psychedelics during the night?

Have you ever wondered why we often take entheogens during the night?

Typically, we take entheogens to find peace of mind outside of our routines. But we can consume these compounds at any time of the day and have the same effect, or wouldn’t we?

Perhaps the connection between both is more ingrained in the exhaustion of our senses and missing our connection to nature than you may think!

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Zebrafish might be the future of studying neuroactive compounds

Fully understanding the mechanisms of action of neuroactive compounds is difficult due to their complexity and polypharmacology. Making single-target drug discovery nearly impossible.

Phenotypic screening was one of the solutions brought by science. However, this method faced historical limitations until recently.

A group of researchers from the University of California found a way to rapidly profile thousands of compounds using larval zebrafish, which share genetics and CNS anatomy with humans, making complex behavioral readouts possible.

Find more here!

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5-MeO-DMT life-changing experiences might have been debunked! 

What we thought to be a toad life-changing trip might be more than that, a new study claims!

For quite some time, the psychonaut community has focused on inducing intense mystical experiences with Bufo Alvarius (Incilius Alvarius), capable of life-changing experiences and altering how we perceive life.

However, new research proves that something else is happening to our brains while such experiences occur within our minds!

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Novel concept of Entheogenic Synergy

Following up on last week’s article, we clear up what we coined as Entheogenic Synergy, which bifurcates into Recreational Synergy and Therapeutic Synergy, concepts intended to raise awareness of anthropological values, mu beliefs, and elements susceptible to changing our biochemistry, microbiota, neurochemistry, and the way we think, such as music, hearing other experiences, expectations, and the journey to our destination, as well as conversations we have about the experience, being present to a new environment and language, learning to adapt, changing our neuroplasticity and thermoregulation are explored as equally as the psychedelic experience, and even further, be included in the psychedelic experience in the future research. 

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Entourage effect of Peyote

The entourage effect is a phenomenon that has been gaining traction in psychedelic research. What at first was thought to be a phenomenon observed solemnly in the cannabis community and the entourage effect between THC and other phytocannabinoids turns out to be much more extensive than what we thought to be and to influence several species such as the Psilocybe genus. One specific study highlighted the significance of this phenomenon by demonstrating the superior therapeutic accuracy of psilocybin extracts compared to synthetic psilocybin.

However, there is a species that hasn’t been spoken of enough when mentioning the entourage effect. Lophophora Williamsii (Peyote).

Join us and understand the entourage effect in Peyote!

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Impact of new Halogenated Tryptophan Derivatives on Psychedelic Research

Groundbreaking research has demonstrated the potential for enzymes to selectively halogenate tryptophan at the 5-, 6-, or 7- positions, with particular emphasis on the 7- position, opening up opportunities to expand bio-based production to different hosts and halogenation positions within tryptophan, making it relevant for a cheaper large-scale industrial production of tryptophan pharmaceutical derivatives.

In the realm of psychedelics, this method could lead to the development of various tryptamine-based psych*delics and new halogenated beta-carbolines that can be used as alternatives to MAOIs in pharmahuasca blends. The possibilities are vast and exciting.

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