Pharmacology

Meet the Fireside project App: Your virtual Peer Support Line

Psychedelic experiences are a trip into the unknown and sometimes get out of hand or become too much to decompress or at least on your own.

Fireside Project considered this and created the first app to help us during and after our trips, with over 100 volunteers to provide you with non-clinical emotional support, giving you a compassionate experience filled with knowledge about the psychedelic realms while always protecting your identity without collecting personal data.

The Fireside Project line is open every day from 11:00 a.m. to 11:00 p.m. PT to everyone in the United States!

Most importantly, it’s free and one click away!

Read more here!

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Our field guide to enter the Psychedelic Space

During my journey of a decade, I’ve met a lot of people who knew about psychedelics, but only a smaller group of people dedicated their lives to educating themselves about these compounds.

When starting your journey, it’s hard to distinguish between the two as every piece of knowledge may seem like a golden nugget. (I assume nowadays it is even more confusing to differentiate the two with the rise of AI tools such as ChatGPT.) 

For this reason, we decided to present you with our field guide to let you know what you should do if you are trying to integrate into the psychedelic space.

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Psychedelic Individualism, a shift on purpose

Recently, there was a shift in Entheogens.

A shift in our purpose.

Entheogens once used to unite the community and are now met with individualism. This shift is nothing but a representation of our society.

We are beginning to absolve the sense of community and become focused on ourselves. Losing communion, compassion, love, and respect for others.

This might be an inevitable step for the evolutionary step, the German band Kraftwerk named Mensch-Maschine (Man-Machine).

Yet, Entheogens can still be the turning point for us to become a community once again.

Find out more!

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Why do we take psychedelics during the night?

Have you ever wondered why we often take entheogens during the night?

Typically, we take entheogens to find peace of mind outside of our routines. But we can consume these compounds at any time of the day and have the same effect, or wouldn’t we?

Perhaps the connection between both is more ingrained in the exhaustion of our senses and missing our connection to nature than you may think!

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Zebrafish might be the future of studying neuroactive compounds

Fully understanding the mechanisms of action of neuroactive compounds is difficult due to their complexity and polypharmacology. Making single-target drug discovery nearly impossible.

Phenotypic screening was one of the solutions brought by science. However, this method faced historical limitations until recently.

A group of researchers from the University of California found a way to rapidly profile thousands of compounds using larval zebrafish, which share genetics and CNS anatomy with humans, making complex behavioral readouts possible.

Find more here!

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5-MeO-DMT life-changing experiences might have been debunked! 

What we thought to be a toad life-changing trip might be more than that, a new study claims!

For quite some time, the psychonaut community has focused on inducing intense mystical experiences with Bufo Alvarius (Incilius Alvarius), capable of life-changing experiences and altering how we perceive life.

However, new research proves that something else is happening to our brains while such experiences occur within our minds!

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Novel concept of Entheogenic Synergy

Following up on last week’s article, we clear up what we coined as Entheogenic Synergy, which bifurcates into Recreational Synergy and Therapeutic Synergy, concepts intended to raise awareness of anthropological values, mu beliefs, and elements susceptible to changing our biochemistry, microbiota, neurochemistry, and the way we think, such as music, hearing other experiences, expectations, and the journey to our destination, as well as conversations we have about the experience, being present to a new environment and language, learning to adapt, changing our neuroplasticity and thermoregulation are explored as equally as the psychedelic experience, and even further, be included in the psychedelic experience in the future research. 

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Entourage effect of Peyote

The entourage effect is a phenomenon that has been gaining traction in psychedelic research. What at first was thought to be a phenomenon observed solemnly in the cannabis community and the entourage effect between THC and other phytocannabinoids turns out to be much more extensive than what we thought to be and to influence several species such as the Psilocybe genus. One specific study highlighted the significance of this phenomenon by demonstrating the superior therapeutic accuracy of psilocybin extracts compared to synthetic psilocybin.

However, there is a species that hasn’t been spoken of enough when mentioning the entourage effect. Lophophora Williamsii (Peyote).

Join us and understand the entourage effect in Peyote!

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