Mushrooms

Prehistoric Psilocybin

Ethnobotanicals are the most antique forms of psychedelic consumption, but for how long have they been around? We have proof of human and animal ingestion around 3,000 years ago, but could species before have also presented the existence of such species?

A newly published study from the University of Utah and the Natural History Museum of Utah suggests that the Psilocybe genus could be around about 65 million years ago!

Join us to uncover a hypothesis of why the genus started developing psilocybin and the first appearance of the fungi during prehistory.

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Remembering Roland Griffiths

The heartbreaking news of Dr.Roland Griffiths’s passing was given to the world yesterday, October 17th. Griffiths was diagnosed with Stage 4 metastatic colon cancer at 76.

Despite his diagnosis to be terminal, he remained optimistic about existence. In an interview with the New York Times, he reminded us that we all are mortal quoting. “We all know that we’re terminal.”

Dr.Griffiths was an illustrious psychopharmacology professor at Johns Hopkins and spent decades studying the mechanism of mood-altering drugs. During his research, he published over 400 scientific papers on opiates and cocaine, sedatives and alcohol, and nicotine and caffeine.

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Fungi art with Michael Campbell

Depictions of nature are possibly the most primal form of art in human history. From cave paintings to surrealistic paintings from modernism, our art has evolved over the years. Influenced by the psychedelic renaissance and the popularization of mycology by lecturers such as Terence Mckenna and Paul Stamets. Such themes brought new eyes to the scene, people with an artistic vein and interested in more than breeding their own fungi, people that saw the beauty in such specimens and began adapting fungi with their special touch birthing wonderful artworks.

Michael Campbell is one of these cases, after being a professor and a student in the field of art, he fell in love with the beauty of nature and started adapting his artworks to thematics such as religion, nature, and fungi.

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The new religion of Psilomethoxin

The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it.

However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it’s yet incognito whether the compound could have any neurotoxicity.

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Psilocybin In the brain

Since the introduction of the Psilocybe genus to the western community, various genetic engineering experiences were made birthing various strains, among them the WillSolvem Peyote Strain.

Recent revolutionary research conducted by the Usona Institute unveiled for the first time the true crystal structure of psilocybin opening doors for new psilocybin analogs, such as CYB003, believed to hold the potential to treat major depressive disorder (MDD) and alcohol disorder. This analog is designed to have less variability in the plasma levels, a faster onset of action, shorter duration, and potentially be more tolerable versus oral psilocybin.

Along with the mycological and chemical discoveries, how the substance acts in the brain and its potential use for the treatment of clinical depression is also being explored together with the hypothesis of psilocybe altering the gut microbiome, thus creating a potential avenue for new pharmaceutical tools targeting the gut-brain axis.

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