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Impact of new Halogenated Tryptophan Derivatives on Psychedelic Research

Groundbreaking research has demonstrated the potential for enzymes to selectively halogenate tryptophan at the 5-, 6-, or 7- positions, with particular emphasis on the 7- position, opening up opportunities to expand bio-based production to different hosts and halogenation positions within tryptophan, making it relevant for a cheaper large-scale industrial production of tryptophan pharmaceutical derivatives.

In the realm of psychedelics, this method could lead to the development of various tryptamine-based psych*delics and new halogenated beta-carbolines that can be used as alternatives to MAOIs in pharmahuasca blends. The possibilities are vast and exciting.

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Australia Leads Psychedelic Therapy Revolution with First MDMA Prescription

Last week, Australia just made history by making the first MDMA prescription. Dr. Ted Cassidy decided to prescribe MDMA to his patient, a female suffering from chronic, treatment-resistant PTSD.

Dr. Cassidy claims that one session of MDMA was equivalent to one year of treatment.

Join us to understand how MDMA can help treat mental illness, the previous history of MDMA psychotherapy, the influence of the Shulgins on various psychotherapists, and various other studies done in the era!

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First atlas of the whole human brain at the single-cell level: What does it mean for Psychedelic Research?

On October 13, 2023, a team of researchers created the most extensive atlas of the human brain thus far, revealing more than 3,000 cell types, including many new to the scientific world. In the atlas, we can observe snapshots of the most complex organ known to man, the brain.

But what does this atlas mean to psychedelic research?

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The new religion of Psilomethoxin

The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it.

However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it’s yet incognito whether the compound could have any neurotoxicity.

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How Psilocybin Affects the Brain: Neuroscience Explained

Since the introduction of the Psilocybe genus to the western community, various genetic engineering experiences were made birthing various strains, among them the WillSolvem Peyote Strain.

Recent revolutionary research conducted by the Usona Institute unveiled for the first time the true crystal structure of psilocybin opening doors for new psilocybin analogs, such as CYB003, believed to hold the potential to treat major depressive disorder (MDD) and alcohol disorder. This analog is designed to have less variability in the plasma levels, a faster onset of action, shorter duration, and potentially be more tolerable versus oral psilocybin.

Along with the mycological and chemical discoveries, how the substance acts in the brain and its potential use for the treatment of clinical depression is also being explored together with the hypothesis of psilocybe altering the gut microbiome, thus creating a potential avenue for new pharmaceutical tools targeting the gut-brain axis.

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Understanding the future of 5-MeO-DMT with Phillipe Henry and Timothy Harvey

The scarcity of the Incilius Alvarius in the wild brought preoccupation regarding the future of the toads, consequently the future of 5-MeO-DMT.
In a conversation with the founder of Egret Bio, Phillipe Henry, and the founder of Lighthouse Genomics Timothy Harvey we were able to understand more about their project Alvarius Research. A project focused on conserving, decoding and editing the genome of the species as well as granting us the biosynthetic reproduction of toad cells.

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KRATOM A TRADITION OR A CRISIS SAVIOR? 

As the Pandemic progresses, the use of Opioids raised massively, with the increase of built-in stress, augmentation of cases of depression, anxiety, and ADHD, people often search for alternatives for their prescribed medication as they are afraid to get hooked into it. In 2020 Kratom took a major step towards its legalization, further information will be discussed by the Royal Thai Gazette, recent studies predict the binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids and users claim that Kratom could be an alternative for their prescription for their mental health.

KRATOM A TRADITION OR A CRISIS SAVIOR?  Read More »

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