PsychedelicsASL

I am a writer focused on the study of psychedelics and pharmacology. Writer of Lophophora as a second language.

The new religion of Psilomethoxin

The new internet-breaking tryptamine Psilomethoxin has generated various discussions on threads. Following breadcrumbs left by Alexander Shulgin, the owners of the Psilomethoxin church claimed to have successfully made the compound and report several experiences using it.

However, the discussion continues, from being a 4-hydroxylated orally active form of 5-MeO-DMT to a potential neurotoxin for its similarities to 4,5-dihydroxytryptamine it’s yet incognito whether the compound could have any neurotoxicity.

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Psilocybin In the brain

Since the introduction of the Psilocybe genus to the western community, various genetic engineering experiences were made birthing various strains, among them the WillSolvem Peyote Strain.

Recent revolutionary research conducted by the Usona Institute unveiled for the first time the true crystal structure of psilocybin opening doors for new psilocybin analogs, such as CYB003, believed to hold the potential to treat major depressive disorder (MDD) and alcohol disorder. This analog is designed to have less variability in the plasma levels, a faster onset of action, shorter duration, and potentially be more tolerable versus oral psilocybin.

Along with the mycological and chemical discoveries, how the substance acts in the brain and its potential use for the treatment of clinical depression is also being explored together with the hypothesis of psilocybe altering the gut microbiome, thus creating a potential avenue for new pharmaceutical tools targeting the gut-brain axis.

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The future of 5-MeO-DMT, a conversation with Phillipe Henry and Timothy Harvey

The scarcity of the Incilius Alvarius in the wild brought preoccupation regarding the future of the toads, consequently the future of 5-MeO-DMT.
In a conversation with the founder of Egret Bio, Phillipe Henry, and the founder of Lighthouse Genomics Timothy Harvey we were able to understand more about their project Alvarius Research. A project focused on conserving, decoding and editing the genome of the species as well as granting us the biosynthetic reproduction of toad cells.

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