Zebrafish might be the future of studying neuroactive compounds
Fully understanding the mechanisms of action of neuroactive compounds is difficult due to their complexity and polypharmacology. Making single-target drug discovery nearly impossible.
Phenotypic screening was one of the solutions brought by science. However, this method faced historical limitations until recently.
A group of researchers from the University of California found a way to rapidly profile thousands of compounds using larval zebrafish, which share genetics and CNS anatomy with humans, making complex behavioral readouts possible.
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